Our interdisciplinary team stretches across the entire United States, spanning three jurisdictions – Idaho, Rhode Island, and Vermont. The researchers are equipped with expertise in computational protein modeling, diverse biological systems, measurement of protein biophysical properties, and mathematical modeling. The group is comprised of talented faculty, postdoctoral fellows, graduate students, undergraduate students and staff.

Meet the team

The RII Track-2 FEC research team consists of researchers and scientists from across the country.


Nearly 35 researchers and scientists gathered for the first time in May of 2018.

Brian Cleveley

University of Idaho
Senior Instructor
Virtual Technology & Design
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Protein [/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques “]
Employing Augmented Reality to explore proteins through the interplay of interactive 3D virtual and physical models. [/expander_maker]

Jean-Marc Gauthier

University of Idaho
Associate Professor
Virtual Technology & Design
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Dynamic virtual protein: visualization, interaction patterns, collaboration with virtual agents, evaluation of user experience. [/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques “] Mixed reality, virtual reality, augmented reality, visualization, interaction design, user interaction, user experience, usability, evaluation, vrtual protein structures, amino-acid. [/expander_maker]

Brent Lockwood

Co-PI

University of Vermont
Assistant Professor
Department of Biology
[expander_maker id=”1″ more=”Model Systems” less=”Read less”] Adaptation to temperature in the eurkaryotic origin recognition complexprotein and alcohol dehydrogenase of the fruit fly Drosophila melanogaster. [/expander_maker][expander_maker id=”2″ more=” Techniques ” less=” Techniques “]
Enzyme assays, fluorescence anisotropy, confocal fluorescence microscopy, reverse genetics. [/expander_maker]

Chris Marx

University of Idaho
Professor
Department of Biological Sciences

Craig Miller

Co-PI

University of Idaho
Assistant Professor
Department of Biological Sciences
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phiX174 and related bacteriophage, their capsid proteins, and their interactions with host bacteria. [/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques “]
Deep mutational scanning, one-pot mutagenesis, golden gate genome assembly, epistasis, statistical modeling. [/expander_maker]

Tanya Miura

University of Idaho
Associate Professor
Department of Biological Sciences
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Respiratory Syncytial Virus (RSV) Fusion (F) glycoprotein. [/expander_maker][expander_maker id=”2″ more=” Techniques” less=” Techniques”]
Reverse genetics/recombinant virus production, virus inhibition assays, virus evolution experiments, flow cytometry, antibody production and purification, mammalian cell culture and transfection, microscopy, cell fusion assays, mutant library design and expression cloning. [/expander_maker]

Mandar T Naik

Brown University
Assistant Professor
Molecular Pharmacology, Physiology and Biotechnology [expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]TEM-1 ß-lactamase, Sea Urchin carbonic anhydrase.[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”] Structure-function relationship, Structural biology and biophysics. [/expander_maker]

Brandon Ogbunu

Co-PI

Brown University
Assistant Professor
Department of Ecology and Evolutionary Biology
[expander_maker id=”1″ more=” Model Systems ” less=” Model Systems “]Dihydrofolate reductase (DHFR), lytic phage, E.coli, in silico fitness landscapes, in silico networks.[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”] Reverse genetics, experimental evolution, chimeric protein engineering, individual-based computer simulations, genetic algorithms, network modeling, analytic modeling
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Jagdish Patel

University of Idaho
Research Assistant Professor
Molecular Modeling
[expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]Protein, protein-protein, protein-ligand, antibody-antigen, membrane protein, virus.[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”] Molecular modeling, molecular dynamics, enhanced sampling techniques, folding stability calculation, binding affinity calculation, homology modeling, structure-based drug design. [/expander_maker]

Melissa Pespeni

University of Vermont
Assistant Professor
Department of Biology
[expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]Alpha carbonic anhydrase, the purple sea urchin Strongylocentrotus purpuratus.[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”] Select and sequence, experimental evolution, next-generation sequencing, bioinformatics and data visualization. [/expander_maker]

Paul Rowley

University of Idaho
Assistant Professor
Department of Biological Sciences
[expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]Virus-host interactions using HIV and viruses of Brewer’s yeast. Killer toxins produced by fungi.[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”] Molecular biology, biochemistry, microbiology, and virology.[/expander_maker]

Brenda Rubenstein

Brown University
Assistant Professor
Department of Chemistry
[expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]Beta-lactamase, PhiX, a range of metalloenzymes[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”] Molecular Dynamics, Monte Carlo, empirical potentials for determining folding free energies such as FoldX and Pyrosetta, docking software such as GLIDE and Autodock Vina. [/expander_maker]

Andreas Vasdekis

University of Idaho
Assistant Professor
Department of Physics
[expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]TEM-1 β-lactamase, population heterogeneity response to point mutations, antibiotics, and temperature.[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”]Bioimaging, microfluidics, stochastic models. [/expander_maker]

Daniel Weinreich

Co-PI

Brown University
Associate Professor
Department of Ecology and Evolutionary Biology and Center for Computational Molecular Biology
[expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]The bacterial drug-resistance enzyme TEM-1 ß-lactamase, lytic phage, the brewer’s yeast Saccharomyces cerevisiae.[/expander_maker] [expander_maker id=”2″ more=”Techniques” less=” Techniques”] Reverse genetics, deep mutational scanning, long-term microbial experimental evolution, individual-based computer simulations, analytic modeling. [/expander_maker]

Holly Wichman

University of Idaho
Professor
Department of Biological Sciences

Marty Ytreberg

PI

University of Idaho
Professor
Department of Physics
[expander_maker id=”1″ more=”Model Systems” less=” Model Systems “]Protein, protein-protein, protein-substrate, antibody-antigen, virus.[/expander_maker][expander_maker id=”2″ more=”Techniques” less=” Techniques”] Molecular modeling, molecular dynamics, folding stability calculation, binding affinity calculation, homology modeling. [/expander_maker]